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Advantage - Application

Is Advantage easy to use?

Yes! Once a month, you simply apply a pre-measured dose from an easy-to-use applicator tube (your veterinarian will prescribe the dosage that's right for your pet). Just part the hair of your pet between the shoulder blades of your dog or on the back of the neck of your cat. Then apply the solution on your pet's skin. That's all there is to it.

Is Advantage sold only through veterinarians?

Yes. Bayer has always had the policy of selling Advantage only through licensed, practicing veterinarians with a doctor-client-patient relationship. It's even right there on our packaging. This is done to ensure you and your pet are getting the best counsel from the person who knows pets and their healthcare best -- your veterinarian.

How fast does Advantage work?

Advantage is the fastest flea control in a tube. Only Advantage claims on its label that it kills 98-100 percent of fleas within 12 hours. Advantage also kills 100 percent of re-infesting fleas within two hours. These rates of kill were supported by an independent, third-party study conducted at the Heinrich-Heine University in Dusseldorf, Germany, by Professor Heinz Mehlhorn1.

According to Mehlhorn, affected fleas exhibited "intense trembling of the legs and pumping movements of the body [and]..remained motionless while the nerves and muscles were constantly and irreversibly destroyed..." Within 10 to 25 minutes of the onset of this reaction, the fleas exhibited no activity and were apparently dead. One hour after exposure, all fleas had died. Since Advantage localizes in the superficial lipid layer of the skin, it remains effective after bathing or repeated water exposure.

The Mehlhorn study concluded that a flea need only come into contact with an Advantage treated pet - not actually bite the pet - in order to receive a lethal dosage. The study states "larval and adult fleas, which only had external contact with imidacloprid-impregnated paper or with shaved hairs from Advantage treated dogs, exhibited reactions similar to those of fleas actually on the skin of Advantage treated dogs." Because of this mode of action, the study also suggests that treatment of pets with imidacloprid may help reduce the incidence of a hypersensitivity skin disorder known as flea allergy dermatitis (FAD)2.

1Mehlhorn, et. al. Effects of imidacloprid on adult and larval stages of the flea Ctenocephalides felis after in vivo and in vitro application: a light- and electron-microscopy study. Parasitology Research (1999) 85:625-637.

2The successive feeding activity of fleas on pets may elicit a hypersensitivity skin disorder known as flea allergy dermatitis (FAD). Treatment of pets with Advantage rapidly kills fleas and may reduce the incidence of this condition.

How can a few drops of Advantage protect my pet from fleas?

Once Advantage is applied to your pet, it spreads on the surface of the skin at the hair root level, aided by body movement, to provide whole body coverage. The revolutionary chemistry causes the flea's nervous system to become impaired, and the flea dies.

What if I still see fleas after using Advantage?

Reinfesting fleas, which likely come from the pet's environment or outdoors, will be killed within two hours, with protection against further flea infestation lasting up to a month.

Will Advantage still work if my pet goes swimming or takes a bath?

Advantage is water-resistant. It continues to work even when your pet gets wet. Advantage works against fleas even after a shampooing, swimming or exposure to rain or sunlight. This is especially important for animals with skin conditions that require bathing and dogs that swim frequently. More importantly, the studies also show repeated treatments are not required because Advantage continues to work even when your pet gets wet.

Should my pet be clean before I apply Advantage?

It is not necessary, but to obtain best results, it is recommended your pet be clean of excess dirt and debris, and be dry before applying Advantage.

What other problems are associated with fleas?

The successive feeding (biting) of fleas on pets may elicit a hypersensitivity skin disorder known as flea allergy dermatitis (FAD). Flea allergy dermatitis, secondary skin infections, tapeworms and even anemia are all medical problems associated with fleas. Flea-related diseases account for more than 50 percent of dermatologic cases presented to veterinarians.

Why do fleas seem to be a non-stop nuisance?

Fleas will jump on your cat or dog, attracted by various stimuli such as body heat, movement and exhaled carbon dioxide. They bite to feed on the blood; then they produce eggs. Eggs drop from your pet to the ground or the carpet. The eggs develop into larvae and over time into adult fleas; then the life cycle starts all over again. A single flea can lay 20-25 eggs per day, so a "few" fleas can become "a lot" of fleas in a short time.


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