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Active Ingredient
Target Specificity
Mode of ActionEmodepside is a semi-synthetic compound belonging to the new chemical group of depsipeptides. It is active against roundworms (ascarids, hookworms and whipworms). In this product, emodepside is responsible for the efficacy against Toxocara canis, Toxascaris leonina, Ancylostoma caninum, Uncinaria stenocephala and Trichuris vulpis.
It acts at the neuromuscular junction by stimulating presynaptic receptors belonging to the secretin receptor family which results in paralysis and death of the parasites.

Praziquantel is a pyrazinoisoquinoline derivative effective against tapeworms such as Dipylidium caninum, Taenia spp., Echinococcus multilocularis and Echinococcus granulosus.
Praziquantel is rapidly adsorbed via the surface of the parasites and acts primarily by changing the calcium (Ca++) permeability of the parasite membranes. This results in severe damage to the parasite integument, contraction and paralysis, disruption of metabolism and finally leads to the death of the parasite

Indication/DescriptionFor dogs suffering from, or at risk from, mixed parasitic infections caused by roundworms and tapeworms of the following species:

Roundworms (Nematodes):
Toxocara canis (mature adult, immature adult, L4 and L3)
Toxascaris leonina (mature adult, immature adult and L4)
Ancylostoma caninum (mature adult and immature adult)
Uncinaria stenocephala (mature adult and immature adult)
Trichuris vulpis (mature adult, immature adult)

Tapeworms (Cestodes):
Dipylidium caninum
Echinococcus multilocularis (mature adult and immature)
Echinococcus granulosus (mature adult and immature)

Special precautions for use in animals
Apply only to the skin surface and on intact skin. Do not administer orally or parenterally.

Avoid the treated cat or other cats in the household licking the site of application while it is wet.

There is limited experience on the use of the product in sick and debilitated animals, thus the product should only be used based on a benefit-risk assessment for these animals.

Special precautions to be taken by the person administering the veterinary medicinal product to animals
Read the package leaflet before use.
Do not smoke, eat or drink during application.
Avoid direct contact with application area while it is wet. Keep children away from treated animals during that time.
Wash hands after use.
In case of accidental spillage onto skin, wash off immediately with soap and water.
If the product accidentally gets into eyes, they should be thoroughly flushed with plenty of water.
If skin or eye symptoms persist, or in case of accidental ingestion, seek medical advice and show the package leaflet or the label to the physician.
Care should be taken not to allow children to have prolonged intensive contact (for example, by sleeping) with treated cats during the first 24 hours after application of the product.
Frequent users of the product (for example, veterinarians, professional cat breeders) should wear disposable gloves when administering the product. Although the product was well tolerated by pregnant cats, studies performed in rats and rabbits suggest that emodepside may interfere with embryo-foetal development. Therefore, women of child-bearing potential should avoid contact with, or wear disposable gloves when administering, the product.

The solvent in this product may stain certain materials including leather, fabrics, plastics and finished surfaces. Allow the application site to dry before permitting contact with such materials.

Echinococcosis represents a hazard for humans. As Echinococcosis is a notifiable disease to the OIE, specific guidelines on the treatment and follow-up, and on the safeguard of persons, need to be obtained from the relevant competent authority.

Adverse reactions (frequency and seriousness) Salivation and vomiting may occur in very rare cases. This is thought to occur as a result of the cat licking the application site immediately after treatment. In very rare cases following administration of Profender transient alopecia, pruritus and/or inflammation were observed at the application site.

Method of administration
For external use only.

Remove one pipette from package. Hold pipette in upright position, twist and pull off cap and use the opposite end of the cap to break the seal.

Part the fur on the cat’s neck at the base of the skull until the skin is visible. Place the tip of the pipette on the skin and squeeze firmly several times to empty the contents directly onto the skin. Application on the base of the skull will minimise the ability of the cat to lick the product off.

Overdose (symptoms, emergency procedures, antidotes), if necessary
Salivation, vomiting and neurological signs (tremor) were observed occasionally when the product was administered at up to 10 times the recommended dose in adult cats and up to 5 times the recommended dose in kittens. These symptoms were thought to occur as a result of the cat licking the application site. The symptoms were completely reversible. There is no known specific antidote.

CAS No Therapeutic antiparasitic agent; ATCvet code: QP52AA51
Chemical NamePraziquantel: 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino(2,1-a)isoquinolin- 4-one
Emodepside: C60H90N6O14
Chemical Structure
Praziqunatel & Emodepside:
Chemical StructureChemical Structure
FormulationsModified release tablets
  Emodepside Praziquantel
Profender Tablets for Small Dogs 3 mg 15 mg
Profender Tablets for Medium Dogs 10 mg 50 mg
Profender Tablets for Large Dogs 30 mg 150 mg
Method of AdministrationFor external use only.
For oral use in dogs from 12 weeks of age and weighing at least 1 kg. Profender tablets are meat flavoured and usually dogs will accept them without any food.
Administer only to fasted dogs. For example overnight fasting is recommended it the dog is to be treated in the morning. Food may be given 4 hours or more after treatment.
DosageProfender is to be administered at a minimum dose of 1 mg/kg body weight emodepside and 5 mg/kg body weight praziquantel, according to the following dosage table.
A single administration per treatment is effective.
Body Weight (kg) Number of Profender tablets for
small dogs
3 kg
medium dogs
10 kg
large dogs
30 kg
1 – 1.5 ½    
> 1.5 – 3 1    
> 3 – 4.5    
> 4.5 – 6 2    
> 6 – 10   1  
> 10 – 15    
> 15 – 20   2  
> 20 – 30     1
> 30 – 45    
> 45 – 60     2

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