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ADVOCATE

Active Ingredient
Category
Target Specificity
Web Addresswww.advocate-spot-on.com
Mode of ActionImidacloprid is effective against larval flea stages and adult fleas. Flea larvae in the pet’s surroundings are killed after contact with a pet treated with the product. Imidacloprid has a high affinity for the nicotinergic acetylcholine receptors in the post-synaptic region of the central nervous system (CNS) of the flea. The ensuing inhibition of cholinergic transmission in insects results in paralysis and death. Moxidectin is a parasiticide which is active against many internal and external parasites. Moxidectin is active against larval stages (L3, L4) of Dirofilaria immitis. It is also active against gastrointestinal nematodes. Moxidectin interacts with GABA and glutamate-gated chloride channels. This leads to opening of the chloride channels on the postsynaptic junction, the inflow of chloride ions and induction of an irreversible resting state. The result is flaccid paralysis of affected parasites, followed by their death and/or expulsion.
Indication/DescriptionDOGS: For dogs suffering from, or at risk from, mixed parasitic infections:
For the treatment and prevention of flea infestation (Ctenocephalides felis), treatment of biting lice (Trichodectes canis), treatment of ear mite infestation (Otodectes cynotis), sarcoptic mange (caused by Sarcoptes scabiei var. canis), demodicosis (caused by Demodex canis), prevention of heartworm disease (L3 and L4 larvae of Dirofilaria immitis) and angiostrongylosis (L4 larvae and immature adults of Angiostrongylus vasorum), treatment of Angiostrongylus vasorum and Crenosoma vulpis and treatment of infections with gastrointestinal nematodes (L4 larvae, immature adults and adults of Toxocara canis, Ancylostoma caninum and Uncinaria stenocephala, adults of Toxascaris leonina and Trichuris vulpis).
The product can be used as part of a treatment strategy for flea allergy dermatitis (FAD).

CATS: For Cats suffering from, or at risk from, mixed parasitic infections:
For the treatment and prevention of flea infestation (Ctenocephalides felis), treatment of ear mite infestation (Otodectes cynotis), prevention of heartworm disease (L3 and L4 larvae of Dirofilaria immitis) and treatment of infections with gastrointestinal nematodes (L4 larvae, immature adults and adults of Toxocara cati and Ancylostoma tubaeforme). The product can be used as part of a treatment strategy for flea allergy dermatitis (FAD).

FERRETS: For Ferrets suffering from, or at risk from, mixed parasitic infections:
For the treatment and prevention of flea infestation (Ctenocephalides felis) and the prevention of heartworm disease (L3 and L4 larvae of Dirofilaria immitis).
CAS No ATC-vet code: QP54AB52
Chemical Name1-(6-Chloro-3-pyridylmethyl)-N-nitro-imidazolidin-2-ylideneamine;23-(O-methyloxime)-F28249 alpha
FormulationsAdvocate for cats and ferrets contains 10% imidacloprid and 1.0% moxidectin Advocate for dogs contains 10% imidacloprid and 2.5% moxidectin.
PresentationPipette Sizes Dog: 0.4ml; 1.0ml; 2.5ml; 4.0ml
Pipette Sizes Cat: 0.4ml; 0.8ml
Pipette Size Ferrets: 0.4ml (combined product small cats / ferrets)
Method of AdministrationDOGS:
Remove one pipette from the package. Then hold the pipette in an upright position, and twist and pull off the cap. Reverse the cap and use it to twist and remove the seal from the pipette, as shown.
Pipette
For dogs up to 25 kg:
With the dog in a standing position, part the coat between the shoulder blades until the skin is visible. Wherever possible apply to undamaged skin. Place the tip of the pipette on the skin and squeeze the pipette firmly several times to empty its contents directly onto the skin.
Dogs up to 25kg
For dogs of more than 25 kg:
For easy application the dog should be standing. The entire contents of the pipette should be applied evenly as 3 or 4 spots along the top of the back, from between the shoulders to the base of the tail. At each spot, part the coat until the skin is visible. Wherever possible apply to undamaged skin. Place the tip of the pipette on the skin and gently squeeze the pipette to expel a portion of its contents directly onto the skin. Do not apply an excessive amount of solution at any one spot, as that could cause some of the product to run down the animal´s side.
Dogs more than 25kg


CATS / FERRETS:
Remove one pipette from the package. Then hold the pipette in an upright position, and twist and pull off the cap. Reverse the cap and use it to twist and remove the seal from the pipette, as shown.
Pipette
Part the fur on the animal's neck at the base of the skull until the skin is visible. Place the tip of the pipette on the skin and squeeze the pipette firmly several times to empty its contents directly onto the skin. Application at the base of the skull will minimise the opportunity for the animal to lick the product. Apply only to undamaged skin.
Cats and Ferrets
DosageDosage schedule for dogs:
The recommended minimum doses are 10 mg/kg bodyweight imidacloprid and 2.5 mg/kg bodyweight moxidectin, equivalent to 0.1 ml/kg bodyweight Advocate for Dogs.

Weight of dog
[kg]
Pipette size to be used Volume
[ml]
Imidacloprid
[mg/kg bw]
Moxidectin
[mg/kg bw]
≤ 4 kg Advocate for Small Dogs 0.4 minimum of 10 minimum of 2.5
> 4 -10 kg Advocate for Medium Dogs 1.0 10 - 25 2.5 - 6.25
> 10 - 25 kg Advocate for Large Dogs 2.5 10 - 25 2.5 - 6.25
> 25 - 40 kg Advocate for Extra-Large Dogs 4.0 10 - 16 2.5 - 4
> 40 kg appropriate combination of pipettes


Dosage schedule for cats:
The recommended minimum doses are 10 mg/kg bodyweight imidacloprid and 1.0 mg/kg bodyweight moxidectin, equivalent to 0.1 ml/kg bodyweight Advocate for Cats.

Weight of cat
[kg]
Pipette size to be used Volume
[ml]
Imidacloprid
[mg/kg bw]
Moxidectin
[mg/kg bw]
≥ 4 kg Advocate for Small Cats 0.4 minimum of 10 minimum of 1
> 4 - 8 kg Advocate for Large Cats 0.8 10 - 20 1 - 2
> 8 kg appropriate combination of pipettes
Dosage schedule for ferrets:
One pipette of Advocate spot-on solution for Small Cats (0.4 ml) should be administered per animal. Do not exceed the recommended dose.



Advocate® is registered under the name Advantage Multi® in some countries. Registration conditions and registered indications and/or target species may differ internationally.

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