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BAYTRIL

Active Ingredient
Category
Target Specificity
Web Addresshttp://www.baytril.com
Chemical ClassQuinolone
Mode of ActionFluoroquinolones interfere with bacterial DNA metabolism by the inhibition of two enzymes, Topoisomerase II (syn. DNA gyrase) and Topoisomerase IV. In Gram-negative organisms, DNA gyrase is the primary target whereas in Gram-positive bacteria, Topoisomerase IV was recently found to be most affected. The function of DNA gyrase is to introduce supercoils into the linear DNA double helix, which results in the highly condensed 3-dimensional structure of the DNA usually present inside the cell. The function of Topoisomerase IV still is barely understood. Models to explain the activity of quinolones at the target site, only exist for DNA gyrase: During the supercoiling process, both DNA strands are cleaved by DNA gyrase at 4 base pair staggered sites, forming a quinolone binding pocket. Two quinolone molecules self-assemble inside the pocket in dimer structure and attach to the gyrase-DNA complex leading to an irreversible block of this intermediate stage of the reaction. Permanent gaps in the DNA strands induce synthesis of repair enzymes (exonucleases), initiating uncoordinated repair processes, which results in irreversible damage to the DNA and, finally, cell death.
Indication/DescriptionAntiinfective (gyrase inhibitor from the fluoroquinolone group of compounds) for the management of diseases of dogs and cats, pigs, cattle and poultry associated with the following enrofloxacin-sensitive Gram-negative and Gram-positive bacteria: E. coli, Salmonella spp., Pasteurella spp., Bordetella spp., Haemophilus spp. and Staphylococci. Baytril is also effective against Mycoplasma. Due to its broad spectrum of activity, Baytril can be used in single or mixed bacterial infections of respiratory and digestive organs, of the urinary tract, of the skin and of wounds. Please note, that registered indications may be different in each country.
Chemical StructureChemical Structure
FormulationsBaytril 15 mg tablet (cats and small dogs) Baytril 50 mg tablet (cats and dogs) Baytril 150 mg tablet (large dogs) Baytril 2.5% injectable solution Baytril 5% injectable solution Baytril 10% injectable solution Baytril Max (Baytril 100) 10% injectable solution Baytril 2.5% oral solution (calves) Baytril 10% oral solution (poultry) Baytril 0.5% oral solution (Pig-Doser)
Method of AdministrationBaytril tablets: for oral use, may be given straight or wrapped up in meat or sausage. Baytril Injectable solutions: for subcutaneous injection in cats and dogs, and for intravenous or intramuscular injection in cattle and pigs. Baytril 2.5% oral solution: to be given in water or milk or milk replacer. Baytril 0.5% oral solution: for direkt oral administration to piglets Baytril 10% oral solution: for oral administration via drinking water.
DosageBaytril tablets: 1 x 5 mg enrofloxacin per kg bodyweight (bw) daily: 15 mg tablet: 1 tablet per 3 kg bw 50 mg tablet: 1 tablet per 10 kg bw 150 mg tablet : 1 tablet per 30 kg bw Baytril 2.5 % Injectable solution: 0.2 ml per 1 kg bw daily. 0.2 ml is equivalent to 5 mg enrofloxacin Baytril 5% and 10% injectable: The dose is 2.5 - 5mg per kg bw or 5 - 10ml 5% injectable solution (resp. 2,5 to 5 ml 10% injectable solution per 100 kg bw Baytril Max (Baytril 100) 10% injectable solution: 7.5 mg / kg bw is equal to 7.5 ml per 100kg bw Baytril 0,5% oral solution (piglet-doser): 1 pump stroke (1ml) per 2 kg bw is equivalent to 2.5mg per kg bw. In severe cases of respiratory disease this dose can be doubled. Baytril 2,5% oral solution: 5ml per 50 kg In severe cases of respiratory disease this dose can be doubled. Baytril 10% oral solution: the dosage is 10mg per kg bw in chicken and turkeys. This equals drinking water concentrations of 50 to 100ml 10% oral solution per 100 litres of drinking water. Duration of treatment and withdrawal periods according to national registrations.

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