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SERESTO

Active Ingredient
Category
Target Specificity
Web Addresshttp://www.seresto.com
Mode of ActionSeresto® contains two active ingredients: imidacloprid which kills adult fleas, flea larvae and lice – and flumethrin, which repels and kills adult ticks, larvae and nymphs. Together, imidacloprid and flumethrin deliver a significantly superior effect on insects than could be expected by adding together the efficacy of the two individual ingredients, as demonstrated in an in-vitro study.
Indication/DescriptionImidacloprid is an ectoparasiticide belonging to the chloronicotinyl group of compounds. Chemically, it can be classified as a chloronicotinyl nitroguanidine. Imidacloprid is active against larval flea stages, adult fleas and lice. Activity against fleas starts immediately after application of the collar. Imidacloprid has a high affinity for the nicotinergic acetylcholine receptors in the post-synaptic region of the central nervous system (CNS) of the flea. The ensuing inhibition of cholinergic transmission in insects results in paralysis and death. Due to the weak nature of the interaction with mammalian nicotinergic receptors and the postulated poor penetration through the blood-brain barrier in mammals, it has virtually no effect on the mammalian CNS. Imidacloprid has minimal pharmacological activity in mammals.

Flumethrin is an ectoparasiticide of the synthetic pyrethroid group. According to current knowledge the synthetic pyrethroids interfere with the sodium channel of nerve cell membranes, resulting in a delay in repolarization of the nerve and finally killing of the parasite. In studies on structure-activity relationship of a number of pyrethroids interference with receptors of a certain chiral conformation was noted thereby causing a selective activity on ectoparasites. No anti-cholinesterase activity was noted with these compounds. Flumethrin is responsible for the product’s acaricidal activity. The product provides repellent (anti-feeding) activity against the claimed ticks, thus preventing repelled parasites from taking a blood meal and thereby indirectly aids in the reduction of the risk of Vector-Borne Disease transmission.

Cats:
For the treatment and prevention of flea (Ctenocephalides felis) infestation for 7 to 8 months. Efficacy against fleas starts immediately after application of the collar.
Protects the animal’s immediate surroundings against flea larvae development for 10 weeks.
Seresto can be used as part of a treatment strategy for the control of Flea Allergy Dermatitis (FAD).

The product has persistent acaricidal (killing) efficacy (Ixodes ricinus, Rhipicephalus turanicus) and repellent (anti-feeding) efficacy against tick infestations (Ixodes ricinus) for 8 months. It is effective against larvae, nymphs and adult ticks.
Ticks already on the cat prior to treatment may not be killed within 48 hours after collar application and may remain attached and visible. Therefore removal of ticks already on the cat at the time of application is recommended. The prevention of infestations with new ticks starts within two days after application of the collar.

Ideally, the collar should be applied before the beginning of the flea or tick season.

Dogs:
For the treatment and prevention of flea (Ctenocephalides felis) infestation for 7 to 8 months. Efficacy against fleas starts immediately after application of the collar.
Protects the animal’s immediate surroundings against flea larvae development for 8 months.
Seresto can be used as part of a treatment strategy for the control of Flea Allergy Dermatitis (FAD).

The product has persistent acaricidal (killing) efficacy against tick infestations (Ixodes ricinus, Rhipicephalus sanguineus, Dermacentor reticulatus) and repellent (anti-feeding) efficacy against tick infestations (Ixodes ricinus, Rhipicephalus sanguineus) for 8 months. It is effective against larvae, nymphs and adult ticks.
Ticks already on the dog prior to treatment may not be killed within 48 hours after collar application and may remain attached and visible. Therefore removal of ticks already on the dog at the time of application is recommended. The prevention of infestations with new ticks starts within two days after application of the collar.
CAS No Imidacloprid: 138261-41-3, Flumethrin: 69770-45-2
Chemical Name-(6-Chloro-3-pyridylmethyl)-N-nitro-imidazolidin-2-ylideneamine (Imidacloprid)

Cyano(4-fluoro-3-phenoxyphenyl)methyl 3-[2-chloro-2-(4-chlorophenyl)ethenyl]- 2,2-dimethyl-cyclopropanecarboxylate (Flumethrin)
Chemical Structure
Imidacloprid & Flumethrin:
Chemical StructureChemical Structure
Method of AdministrationCutaneous use. One collar per animal to be fastened around the neck. Cats and small dogs up to 8 kg body weight receive one collar of 38 cm length. Dogs above 8 kg receive one Seresto collar for dogs > 8 kg of 70 cm length. For external use only.

Remove collar from protective bag directly before use. Unroll collar and make sure that there are no remnants from the plastic connectors inside the collar. Adjust the collar around the animal's neck without tightening it too tight (as a guide, it should be possible to insert 2 fingers between the collar and the neck). Pull excess collar through the loop and cut off any excess length extending beyond 2 cm.

Method of Administration

The collar should be worn continuously for the 8 month protection period and should be removed after the treatment period. Check periodically and adjust fit if necessary, especially when kittens/puppies are rapidly growing. This collar is designed with a safety-closure mechanism. In the unlikely event of a cat being trapped, the cats own strength is sufficient to widen the collar to allow for quick release.
DosageOne collar of 38 cm (12.5 g) contains 1.25 g imidacloprid and 0.56 g flumethrin as active substances.
One collar of 70 cm (45 g) contains 4.5 g imidacloprid and 2.03 g flumethrin as active substances.

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